Kristen Wiig and Bill Hader Sparkle in New ‘Skeleton Twins’ Trailer

Kristen Wiig is back on the big screen and reuniting with Saturday Night Live castmate Bill Hader in the official trailer for their latest film The Skeleton Twins. The two, who have played mother and son and husband and wife in the past, now play a pair of depressed twins, Maggie and Milo, who are forced to reunite after a decade of estrangement due to extreme circumstances.

In the film, Maggie and Milo come face-to-face for the first time in ten years after each twins tries—and fails—to commit suicide. Maggie is struggling to stay on the same page with her husband Lance (Luke Wilson), who desperately wants kids. Meanwhile, Milo is a gay man dealing with a non-existent acting career and the aftermath of a tumultuous relationship with a former lover (Ty Burrell). During their time together, the two begin to take a closer look at their relationships and lies and are surprised to learn that they may get along better than expected.

The R-rated film, out in theaters on September 19, won the Waldo Salt Screenwriting Award in the U.S. Dramatic category at Sundance for Mark Heyman and Craig Johnson, who also directed the flick. But while the movie marks a significantly more serious turn for both actors, there are still plenty of funny moments in the trailer, including a can’t-miss, hilarious scene featuring the two lip-synching to Starship’s “Nothing Gonna Stop Us Now.”

Not to mention, the chemistry between Hader and Wiig is undeniable. Even while taking on more dramatic issues like suicide and infidelity, the two sparkle in a way that’s more than enough to make fans of either actor want to go see the movie.