10. High blood pressure
Though we talked about estrogen being the issue before when it comes to your heart, it’s progesterone that can cause your blood pressure to rise. Verywell explains progesterone has a direct effect on your small blood vessels, which can increase in pressure. If you have a family history of high blood pressure, especially for women, you’re at an increased risk. That doesn’t mean the pill is off limits — it usually just means your doctor will monitor you and switch you to a low-progesterone pill if necessary.