2. Contrave (bupropion and naltrexone)
Contrave can cause some seriously scary psychiatric side effects, but it was approved in 2014 as a weight loss pill. It contains both bupropion (an antidepressant) and an ingredient used in Zyban (a medication used to stop smoking). The medication has not been approved for depression or smoking cessation, but it comes with the side effects often found in pills used for such purposes.
Those side effects include mood changes (depression or mania), psychosis, hallucinations, paranoia, delusions, and thoughts of suicide.