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Over the years, ABC’s Grey’s Anatomy had numerous famous guest stars on the show. Since the show aired in 2005, notable celebrities have graced the halls of Grey Sloan Hospital, whether it be playing a prominent surgeon or a patient. Here is a list of six famous guest stars you might not remember appeared on the long-running medical drama.

Demi Lovato played a sick patient in ‘Grey’s Anatomy’

Demi Lovato in a white hospital gown in ABC's 'Grey's Anatomy.'
Demi Lovato | Mitch Haddad/Disney General Entertainment Content via Getty Images

Former Disney star Demi Lovato played a teenage girl named Hayley May. In season six, she came to Grey Sloan Hospital seeking help for her misdiagnosis. Before arriving, May received a diagnosis of paranoid schizophrenia. But, she knew something else was wrong. Dr. Alex Karev (played by Justin Chambers) uncovered her actual diagnosis. Then, May undergoes surgery and is grateful for her new lease on life.

‘Lovecraft Country’ star Jurnee Smollett played a patient in ‘Grey’s Anatomy’

Jurnee Smollett laying in a hospital bed in ABC's 'Grey's Anatomy.'
Jurnee Smollett | Michael Desmond/Disney General Entertainment Content via Getty Images

Prior to fighting villainous monsters in the HBO series Lovecraft Country, Jurnee Smollett played a patient in Grey Sloan Hospital. In season four, the actor played a young woman named Beth Monroe. According to Insider, she had an inoperable tumor and was madly in love with her boyfriend, who had the same condition. Both patients were chosen to participate in Meredith Grey and Derek Shepherd’s clinical trial. Spoiler alert, she survives the surgery, but her boyfriend doesn’t.

Sarah Paulson portrayed a prominent surgeon in the medical drama

Before appearing in the FX anthology series American Horror Story, actor Sarah Paulson played a younger version of Ellis Grey in Grey’s Anatomy. In season six, young Ellis and Dr. Richard Webber appear in a flashback. According to Bustle, they were both caring for a patient diagnosed with GRID, later referred to as AIDS.

Former Nickelodeon star Keke Palmer guest stars on ‘Grey’s Anatomy’

Singer and actor Keke Palmer made a special appearance in Grey’s Anatomy Season 10. Palmer played a teenage girl named Sheryll Jeffries. She is in dire need of a heart transplant and happens to be pregnant. So, the young woman wants to participate in Cristina Yang’s (played by Sandra Oh) clinical trial. Cristina denies her access to the trial. Later, she gives birth to a premature baby. 

Millie Bobby Brown starred in the ABC hit series before ‘Stranger Things’

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Not long before starring in the Netflix hit series Stranger Things, Millie Bobby Brown played a young girl named Ruby on the medical drama. After her mom gets injured from an earthquake, doctors talk Ruby through rigorous medical procedures to save her. While on the phone, she performs CPR on her mother before the helicopter arrives to rescue them.

Emmy-award winning actor Elisabeth Moss shined in the medical drama

The Handmaid’s Tale star Elisabeth Moss played Nina Rogerson in Grey’s Anatomy Season 3 Episode 19. Nina’s mother was admitted into Grey Sloan hospital to undergo extensive surgery for a rare bone disorder. She is very protective of her mother and goes against the surgery. When her mother wants the procedure, Nina is hesitant but supportive. Later, her mother dies from the surgery.