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Following her death in 1997, Princess Diana was given an appropriate nickname, the “People’s Princess.”

She was referred to as such because of her warmth, compassion, and ability to connect with people all around the world. The nickname is one she truly earned over the years for her hands-on humanitarian work, such as touching AIDS patients.

Here’s how Princess Diana really changed the world (and everyone’s thinking) with a single, gloveless handshake.

The year was 1987 and the world was gripped by fear, misunderstanding, and stigma. HIV/AIDS was still shrouded in mystery and ignorance. Many believed the virus could be spread by a simple touch. Hospitals often kept patients isolated. Families struggled with shame. Even the medical staff were hesitant. Amid this climate of fear, Princess Diana stepped into a small ward at London’s Middlesex Hospital and made history with a single, gloveless handshake.

The room was quiet, tense even. Cameras clicked, journalists watched, and a young man lay in a hospital bed, clearly weak, his eyes darting nervously toward the approaching princess. Most visitors kept their distance. But Diana didn’t. She smiled warmly, stepped forward, and gently reached out. No gloves. No hesitation. Her bare hand took his, and she held it. That simple act — a human touch — shattered a global illusion.

At the time, the belief that HIV could be transmitted through casual contact was widespread. Public education hadn’t caught up to science. People with AIDS were treated like outcasts, feared as though they carried the plague. But here was the most photographed woman in the world, touching an AIDS patient with tenderness, empathy, and dignity. It wasn’t just a handshake. It was a declaration: These people are not untouchable. They are human.

The impact was immediate. The photo of the then-Princess of Wales holding the patient’s hand raced around the world. Newspapers ran it on their front pages. Evening news anchors used the moment to begin conversations about compassion, science, and human decency. For millions, Diana’s gesture challenged long-held beliefs and fears.

Diana understood something profound: that stigma kills as effectively as any virus. Her empathy wasn’t performative. It was transformative.

As the princess famously said once, “HIV does not make people dangerous to know. You can shake their hands and give them a hug — Heaven knows they need it.”

She wasn’t a scientist. She wasn’t a politician. But with that single act of kindness — one uncovered hand extended in compassion — she did what neither science nor politics could fully achieve at the time. She opened the hearts and minds of millions.

Looking back now, nearly four decades later, it’s easy to forget just how radical her actions were. Today, we understand HIV far better. We know it can’t be spread by touch, and treatments allow many to live long, healthy lives. But none of that progress happened in a vacuum. It began with moments of courage. And Diana’s handshake — that quiet, single, gloveless act of rebellion against fear — is one of the most iconic.