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Throughout six seasons of the storylines surrounding This Is Us‘ Pearson family, fans have been treated to many interesting, heartbreaking, and unforgettable tales. The NBC series told the true story of a family and all of its ups and downs, spanning decades of life. Although every character arc brought something special to the table, some of the series’ most extraordinary and unforgettable storylines have become what its lead actors are most proud of.

Chrissy Metz, Sterling K. Brown, Justin Hartley, Milo Ventimiglia and Mandy Moore in side by side photographs promoting 'This Is Us.'
Chrissy Metz, Sterling K. Brown, Justin Hartley, Milo Ventimiglia and Mandy Moore | Ron Batzdorff/Jeff Lipsky NBCU Photo Bank

‘This Is Us’ has unpacked a lot of topics over six seasons

This Is Us changed storytelling on network television and unpacked a lot of tough topics.

The series’ key characters included Jack Pearson (Milo Ventimiglia), his wife Rebecca (Mandy Moore), and their adult children Kevin (Justin Hartley), Randall (Sterling K. Brown), and Kate (Chrissy Metz).

Subsequently, some of the show’s supporting characters included Beth (Susan Kelechi Watson), Miguel (Jon Huertas), Madison (Caitlin Thompson), Toby (Chris Sullivan), and Nicky (Griffin Dunne).

A handful of the series’ key storylines have focused on important life issues.

These included infertility, living with a disability, alcoholism, family conflict, and racism.

Also tackled were mental health, body image, PTSD, LGBQT+ struggles, late-in-love romance, infidelity, elder care, and death.

However, what were some of the favorite storylines of the series actors, who brilliantly acted out these challenging character arcs?

‘This Is Us’ Cast Reveals Extraordinary Storylines They’re Most Proud of

Kevin (Justin Hartley) ran to be by his brother Randall’s (Sterling K. Brown) side during an anxiety attack in season 2.

Milo Ventimiglia Can ‘Hang up’ Jack Pearson but He Won’t Forget This One Special Thing About ‘This Is Us’

In an interview with E! News, the cast of the NBC family drama spoke of the extraordinary storylines they’ve been most proud to feature throughout the six seasons of the series.

Ventimiglia said he was most proud of telling Jack’s story regarding his experiences with alcoholism and the character’s life in Vietnam. However, he was most proud of portraying a “guy who didn’t come from a good family wanting to have a good family.”

“The fertility struggles storyline with Kate and Toby a lot of people connected to,” Sullivan admitted. He also cited other storylines that provided an important “context to begin conversations.”

However, Metz cited the “racial injustice that Randall went through” and the call to action that fans realized from the topic. 

“I loved Tess’ coming out,” claimed Watson. “A lot. I mean, a lot.”

Perhaps Hartley summed up the overall feel of the cast when he said, “I mean, who would have ever thought as an actor that you get an opportunity to be on a show like this, that impacts so many people’s lives that you will never meet? What an absolute treat.”

When does ‘This Is Us’ end its run on NBC?

The final episode of This Is Us airs Tuesday, May 24.

However, the series will finish its six-season run with three remaining episodes.

These are called “Family Meeting,” “The Train,” and “Us.”

This Is Us airs Tuesdays at 9 p.m. EST on NBC.