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As Super Bowl LX approaches, Serena Williams is set to star in a high‑profile commercial for telehealth company Ro, marking the brand’s first‑ever Super Bowl ad. The 30‑second spot is part of Ro’s new “Healthier on Ro” campaign. And it features Williams candidly discussing her personal experience with GLP‑1 medications, a class of drugs used for weight management and metabolic health. Rather than focusing on aesthetics alone, the ad aims to destigmatize GLP‑1 use and redefine it as legitimate healthcare. But the ad is already causing a debate amongst fans. Here’s what to know.

Serena Williams stars in a new 2026 Super Bowl ad from Ro that highlights her weight loss

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Tennis legend Serena Williams is set to appear in a 2026 Super Bowl ad for Ro, a direct‑to‑patient telehealth company best known for prescribing GLP‑1 medications for weight management and metabolic health. Williams publicly shared that after struggling to lose weight post‑motherhood, she found success with GLP‑1 treatment. She chose Ro as her care provider, a decision she now uses to advocate for a scientific, stigma‑breaking approach to weight and health care.

Now, Williams serves as a brand ambassador. And the new Super Bowl ad has her discussing how she lost 34 pounds with the help of the medication.

“Thirty-four pounds down on GLP-1s,” she says in the ad while injecting herself in the arm with the treatment. “Healthier on Ro. Supported on Ro. FDA-approved GLP-1 options. Now, even in a pill. Weight-loss expertise I trust.”

Williams goes on to say how she’s “moving better” and “feeling better” on Ro while dancing and flexing in the ad. “I’m Serena Williams. This is me on Ro.”

Saman Rahmanian, Ro’s co-founder and chief product officer, explained how having Williams as part of the ad was to show how taking GLP-1s isn’t considered “cheating” or a “shortcut.” And Rahmanian wants to dispel any myths surrounding the meds with the Super Bowl ad.

“We’re going to dispel a second myth around GLP-1s, which is that weight-loss medications are only for vanity,” he said, according to PRWeek. “We know that GLP-1 meds are more than skin deep.”

Super Bowl aside, the broader Ro campaign will include other big names, like NBA Hall of Famer Charles Barkley, as well as everyday people who use the product.

“We explored a lot of different angles … probably went through 150 different concepts, but ultimately, we decided to focus on this broader health story,” Rahmanian said.

Fans are divided on the Ro ad

Serena Williams’ Super Bowl Ro ad will certainly divide fans. While many tennis lovers have been supportive of Williams’ journey, others have questioned her usage of GLP-1s. Additionally, Williams’ husband, Alexis Ohanian, is an early investor in Ro, sparking additional debate regarding her involvement.

Several followers loved the ad and noted that Williams looks incredible following her weight loss.

“She does look great tbh,” one fan commented.

“How cool is this? Fantastic job Ro team!” another fan wrote.

However, others aren’t so sure about Williams’ support of the company.

“Products for the unhealthy advertised by the extremely healthy … ever so funny to see,” another YouTuber commented.

This aligns with how fans felt when Williams initially opened up about her GLP-1 usage. While she’s been open with her fans about the benefits of the medication, she experienced significant backlash.

Is Serena Williams returning to professional tennis?

With Super Bowl LX just days away, speculation has been building that Serena Williams might use her high‑profile appearance in the Ro commercial to hint at or even announce a return to professional tennis. Rumors have gained traction after Williams was spotted back on the International Tennis Integrity Agency’s Registered Testing Pool list. This is a procedural step required for any player considering a comeback. And it fueled talk among fans and media that a big reveal could land in front of the national Super Bowl audience.

Williams has publicly denied plans to return. She most recently stated “I’m NOT coming back” on social media, according to Tennis.com, and adopted a non‑committal stance in interviews. However, she still has not publicly stated that she’s entered retirement, further fueling the rumors.

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